Winners Announced in 2026's 'International Obfuscated C Code Competition' | | Yesterday 2026's International Obfuscated C Code Contest concluded, with 22 new winners announced in a special three-hour livestreamed ceremony! Started 42 years ago, it's been described as the internet's longest-running contest, with entrants concocting convoluted programs glorying in the C programming language's subtleties, all while having some fun. And "For IOCCC29, the volume and quality of submissions were at near-historic heights," explains its home page.
There's a "Tetris-optimized" GameBoy emulator and a quasi-Rogue-like game, with awards also given for the best imaginary emulator (a virtual machine in 366 bytes of C) and the best fractional emulator (a maze generator for the Commodore 64). But every one of the 22 winning programs seems wildly creative...
Quine Pong. "Running the program produces the source code to generate the next frame, formatted to display the current frame. By repeatedly compiling and running each successive frame, you can play the game. To move, pass either "w" (up) or "e" (down) as an argument..."
A winning Taiwanese programmer formatted their source code in the shape of a Tardis from Doctor Who — code that displays an intricate ASCII animation of Doctor Who's 1963 opening title sequence.
One winning entry emulates an IBM 7040 mainframe, first converting a program (encoded in whitespace) into ASCII-character drawings of punchcards for a FORTRAN program — and then executing that program to calculate the light visible to an observer looking at black hole, ultimately creating an image. It's all recreating what astrophysicist Jean-Pierre Luminet had to do in 1978 to generate the first-ever simulated photograph of a black hole (on an IBM 7040 mainframe). "The entry can also run other FORTRAN programs — but "they must be provided as a deck of punch cards... Tools have been provided to convert to/from decks and to interpret..."
"We have added fun challenges to this year's winning entries competition..." the web site notes. "After you figure out what a given winning entry does, we encourage you to attempt the fun challenge!"
Thanks to long-time Slashdot reader achowe for bringing the news (who has submitted winning entries in four different decades, starting in 1991 and continuing through 2025) — and who won again this year for a program simulating the Space Invaders-like game from Casio's 1980 MG-880 calculator.
Follow the IOCCC on Mastodon. Read more of this story at Slashdot. |
James Bond Videogame '007 First Light' Sells 2.2M Copies, Earns $150M | | The new James Bond-themed videogame 007 First Light had a budget of 1.3 billion Danish krone — a little more than USD $202 million, reports IGN, citing a report from Denmark's public service broadcaster. "Denmark's TV 2 said that makes 007 First Light the most expensive entertainment product in the country's history" — and the game "still has some way to go before breaking even."
007 First Light is estimated to have sold 2.2 million copies, generating $150 million in revenue... The only official sales data we have comes from developer IO Interactive, which said that 007 First Light had become the fastest-selling game in the company's history, shifting 1.5 million copies in its first 24 hours... The impressive sales milestone was achieved without the aid of the Nintendo Switch 2 version, which is due out this summer. The James Bond adventure is also the highest rated IOI game ever, with an 87 on Metacritic...
The developer has said it wants to make a trilogy of James Bond games.
Game-tracking company Alinea Analytics tweeted their estimates that 55.1% of sales were on PS5, 33.1% on Steam, and 11.8% on Xbox (Xbox console, Windows, and cloud combined).
And Polygon reports that new downloadable game content was announced Friday. Read more of this story at Slashdot. |
After Empty Promises, Will String Theory Find New Uses? | | Science magazine reports:
For decades, string theory promised a "theory of everything" that described all particles and forces as tiny vibrating strings. Physicists hoped it could also solve one of the field's deepest problems: reconciling quantum mechanics with gravity. But as string theory grew increasingly elaborate — and experimentally unreachable — many physicists lost hope.
Now, some researchers are revisiting the theory from first principles. In a paper in press at Physical Review Letters, Clifford Cheung, a physicist at the California Institute of Technology, and colleagues lay out a small set of assumptions about the universe and show that they inevitably give rise to string theory.... Cheung's study, along with another one posted to arXiv in January, starts with two reasonably conservative assumptions: that the probabilities of all possible outcomes of an event add up to 100%, and that the laws of physics are consistent for observers moving at different speeds. Each group then posits additional assumptions that have not been borne out by observations. Cheung's analysis invokes "ultrasoftness," the idea that the probability of certain particle interactions drops off at a particular rate at high energies. The second study, led by University of Michigan physicist Henriette Elvang, instead assumes "supersymmetry," a maximal coupling between matter and forces. Both groups conclude the only theory that can satisfy their assumptions is one that looks like string theory...
Cheung and Elvang stress that their aim is not to prove the inevitability of string theory. "I don't have a dog in the fight; I just work here," Cheung says. Rather, the goal is to explore the space of possible theories under rigid constraints — regardless of whether they reflect reality... The one thing the researchers all agree on is that the field would benefit from more alternative models to string theory. Cheung sees the agnostic, bottom-up exploration as a step in that direction. "You can either give up on the problem because it's too culturally toxic, or you can ask: If you want to find an alternative, what do you need?" he says. "Now, we know exactly what to do."
Thanks to Slashdot reader sciencehabit for sharing the article. Read more of this story at Slashdot. |
Reddit Ads Impersonate BBC and The Guardian to Push Fake AI Investment Schemes | | A "growing wave" of Reddit's "promoted posts" are sending U.S. and European audiences to money-stealing scams that impersonate major news organizations including the BBC, the Financial Times, and The Guardian, according to new findings from Bitdefender Labs.
"Domains are short-lived and rapidly rotated to evade detection," they write, noting that the impersonating sites apparently even use language "to falsely imply that the investment platform had been reviewed, approved, or vetted" by the legitimate site they're impersonating:
The campaign promotes fake AI-powered investment platforms such as Wencoin STX, Warrior Coin AI, and Nevo Coin, using fabricated celebrity endorsements, cloned news websites, fake interviews, and invented financial success stories to lure victims into depositing money. Researchers Andrea Olariu and Emanuel Puscasu have identified multiple promoted Reddit posts masquerading as legitimate financial or breaking news stories.
Some ads claimed that:
— NVIDIA and OpenAI were "creating the future"
— Heathrow police discovered hundreds of thousands of pounds in cash
— Governments and banks were allegedly trying to "hide" a revolutionary AI investment platform
— European regulators were "silencing" articles about AI trading systems
Some Reddit ads delivered in video format, including what appeared to be a deepfake BBC news segment featuring a news anchor presenting fabricated financial headlines... Examples observed by researchers included:
— Fake BBC pages discussing "$20 billion conversations" tied to AI investments
— Fraudulent Financial Times articles about Heathrow airport cash seizures
— Fake Guardian stories claiming governments were trying to suppress coverage of Wencoin STX or Nevo Coin
The pages featured fabricated interviews, fake profit screenshots, manipulated banking documents, false testimonials, and even fictional journalists or business editors designed to make the scam look legitimate. In many cases, the content sought to create a sense of exclusivity or conspiracy, suggesting that banks, regulators, or governments were trying to suppress public access to the investment platform...
Our researchers found that after users clicked links embedded within the fake Guardian articles, they were redirected to a registration form allegedly used to create a "Nevo Coin" investment account. The form requested personal contact information, including the victim's name, email address, and phone number. To increase pressure and encourage immediate action, the page warned that registration availability was limited, claiming that once all spots were filled, new user registrations would be suspended.
And in the final stage, they're asked to deposit money... Read more of this story at Slashdot. |
Donald Trump, Bernie Sanders And Sam Altman Are All Talking About Public Ownership In AI | | U.S. Senator Bernie Sanders announced a plan for the public to take a 50% ownership stake in AI companies, remembers the Associated Press.
And then OpenAI's Sam Altman "told Sanders that he, too, wants the public to have equity in AI companies."
Though the CEO said he couldn't support Sanders' threshold of 50%, he nonetheless wanted to work with him to advocate for the general idea, according to people with knowledge of the conversation. The nearly hourlong meeting in Sanders' Senate office this week, held at Altman's request, highlighted the inherent tension between AI powerhouses and policymakers as Americans are increasingly asked to accept the costs of the AI boom even as they remain unconvinced of its direct benefits.
Yet it's also creating odd political bedfellows fueled by populism as politicians from Sanders to President Donald Trump embrace giving the public a stake in AI's growth. Speaking to reporters on Air Force One on Friday, Trump described a potential partnership "where the American people can benefit from the success of AI" and said executives from leading AI companies will visit the White House, "probably next week," to discuss the idea.
The article points out that Altman also met with congressional leaders from both of America's political parties. Read more of this story at Slashdot. |
'Steve Jobs In Exile' Remembers the Birth of the Web and 'Making Unix Taste Sweet' | |
Ars Technica shares some anecdotes from Steve Jobs in Exile, a new book released last month:
[Author Geoffrey] Cain reminds us, in stunning detail, that Jobs' "exile" era at NeXT was not only critical to his evolution as a man and an entrepreneur, but that it mattered for the rest of us, too. The technological innovations that came out of NeXT — notably, the NeXTSTEP OS — continue to live on in what we now call both macOS and iOS. As Cain puts it, "NeXTSTEP was Steve's attempt to make Unix taste sweet...."
[W]hile many tech nerds know that Tim Berners-Lee created the first World Wide Web server on a NeXT machine while working in Switzerland in 1990, few know that NeXT employees were wary of bringing the news to Jobs. Why? They feared his wrath "and that he would dismiss [the web] as 'shit.'" (In another timeline, NeXT might itself have capitalized on this world-changing innovation....)
Perhaps one of the wildest anecdotes that Cain uncovered was how one voicemail changed computer history forever. In 1996, when Apple was solidly in its mediocre Performa era — and considering buying BeOS as the basis for its new operating system — a mid-level NeXT product manager asked aloud, "Why don't we just frickin' call Apple?" (NeXT was also struggling during this period.) And so someone did. As Cain writes:
Garrett left the group of managers, walked back to his office, and took a risk. He picked up his designer phone and called the head of software at Apple. He left what he described as "one of my more inspired sales pitches" on the man's voicemail, explaining why Apple should be looking at NeXT instead of Be... In any other universe, Garrett's call might have gotten him fired. But in this timeline, it worked out. And thanks to him, Steve [Jobs] was about to enter Apple's airspace once again.
Thanks to long-time Slashdot reader destinyland for sharing the article. Read more of this story at Slashdot. |
Scientists Edited Human Embryo Genes. But Questions Remain | | "A DNA-editing feat involving editing the genes of early stage embryos was announced this week," reports the Wall Street Journal.
They describe the feat as "a far cry from designer babies, but nevertheless a step in that direction."
Dieter Egli, an associate professor of developmental cell biology at Columbia University and his co-authors, including Nathan Treff of Nucleus Genomics, a New York-based DNA-testing startup, say the technology could help fix disease-causing mutations in embryos. "We're not throwing the final 'OK, you will have gene-edited babies tomorrow' at the public," said Egli. "That is a process that can occur through discussion matched with scientific progress...."
Previous gene-editing efforts have often used Crispr, which can cut out parts of the DNA sequence, but the technology can also cause damage if the wrong DNA is targeted or cut out. In 2018, Chinese scientist He Jianku said he used Crispr to tweak DNA in human embryos and was imprisoned for the work. The technology Egli's group used, called base editing, allows them to target individual DNA letters in sequences more precisely with fewer adverse effects... Egli's group focused on altering two genes, one that can raise the risk of heart disease and one that is tied to blood disorders like sickle cell disease, and the research showed they were sometimes able to do so successfully, in the same embryo, without damage.
"I am generally supportive of the concept of embryo editing to prevent genetic disease," said Dr. Paula Amato, a fertility expert at Oregon Health & Science University who wasn't involved in the research... Base editing has been used in human embryos before, according to peer-reviewed studies. The technology was used to correct a disease-causing mutation and an Alzheimer's disease-risk gene variant, said Alexis Komor, associate professor of biochemistry and molecular biophysics at the University of California, San Diego, who wasn't involved in the work. "There really is not any unmet medical or clinical need for this, especially from an in vitro fertilization perspective," Komor said. "Usually what you'll hear is that they're doing it just so that you know we can prevent genetic diseases, but there are so many other better ways to do that."
Using embryo editing to create babies is illegal in the U.S. and many other countries. Scientists have long worried that it is a slippery slope and that the technology could ultimately be used to promote eugenics. Her worry is that "they're basically building a blueprint" for more ethically problematic forms of embryo editing.
"In my opinion, I think this is a huge no-no," Komor said. "There's just no ethical way to use this...."
Nucleus Genomics Chief Executive Kian Sadeghi said his company plans to fund Egli's further research, building on the new findings. His company sells a polygenic embryo-screening product, which screens prospective parents' embryos and produces risk scores for their likelihood of developing disease, as well as factors like height, IQ and eye color. The company has said the IQ predictions are limited in accuracy.
The research was published online Monday on a preprint server. Read more of this story at Slashdot. |
Failing CS Grades Soar At UC Berkeley As Professors See Greater AI Usage | | The University of California at Berkeley discovered the percentage of failing grades in multiple CS classes this spring "is significantly higher than past semesters," reports the campus's student newspaper.
"Instructors point to students' increased reliance on AI, lack of mathematical preparedness and understaffing as potential contributing factors."
According to [coursework platform] Berkeleytime, 35.3% of CS 10 students and 10.6% of CS 61A students received F's in spring 2026. In spring 2025 and spring 2024, the percentage of F's did not exceed 10% for either class. The electrical engineering and computer sciences department's grading guidelines state that 7% of students in lower division courses, including CS 10 and CS 61A, should receive D's and F's...
[UC Berkeley teaching professor Dan Garcia, who taught both classes] believes the "primary driver" of these abnormally high failing rates is due to a "vast increase in academic dishonesty" due to students' usage of large language models, such as Claude, ChatGPT and Google Gemini. "Some of the numbers that you saw from the number of students who receive failing grades were because we caught them (cheating) and prosecuted them and are sending their cases to the Center for Student Conduct," Garcia said. "But in other cases, it's students who are leaning a little too hard on LLMs to do their work for them, and then at exam time just really aren't ready." According to Garcia, nearly 30 students in CS 10 were "caught cheating on take-home exams" in spring 2026...
In addition to overreliance on AI, Garcia also pointed out that many students are underprepared mathematically, a concern echoed by campus associate teaching professor Gireeja Ranade. Ranade noticed a similar lack of prerequisite mathematical skills in her spring 2026 EECS 127 class, "Optimization Models in Engineering," which she described as "differently challenging" to teach this semester. The class saw a 16.8% F rate, far higher than the 5% of D's and F's that the EECS department describes as "typical" for an upper division course...
Both Garcia and Ranade have joined more than 1,300 UC faculty in signing a petition calling for the reinstatement of ACT and SAT standardized testing scores for STEM admissions in the UC system.
Thanks to long-time Slashdot reader theodp for sharing the article. Read more of this story at Slashdot. |
Cheaper EV Sales are Increasing | | Sales have increased for Hyundai's under-$35,000 IONIQ 5, totalling 18,395 for the first five months of 2026, reports Electrek, "up 16% from the same period last year."
But meanwhile BYD's overseas sales surpassed 160,000 for the first time last month, "up 80% from May 2025 and 19% from the previous record of 135,098 set in April."
Through the first five months of 2026, BYD sold 616,263 vehicles overseas. In May, overseas sales accounted for over 41% of BYD's total sales. In several major markets, including the UK, BYD surpassed Tesla and Kia to become the best-selling EV brand through April. "With fuel prices remaining high, more drivers are turning to electric vehicles as a smarter and more economical choice," Bono Ge, BYD UK's Country Manager, said last month.
Elsewhere Electrek notes that Toyota's bZ (starting at under $35,000) was the third-best-selling EV in the U.S. in the first three months of 2026, behind only the Tesla Model 3 and Model Y. "Last month, bZ sales doubled from May 2025, with 2,646 units sold."
And meanwhile the first Volkswagen ID. Polo and Cupra Raval models "rolled off the production line at the Group's Martorell plant in Spain, the first of several new affordable, mass-market EVs."
Starting at €24,995 ($29,000) and €26,000 ($30,100), the ID. Polo and Cupra Raval are the first models from the Group's Electric Urban Car Family...
[T]he first customer deliveries are scheduled to begin later this summer and into the fall. Following the ID. Polo and Cupra Raval, Volkswagen will introduce new members to the Electric Urban Car Family, including the ID. Cross, an electric version of the T-Cross, later this year.
According to Volkswagen, the ID. Cross will start at around €28,000 ($32,500). Read more of this story at Slashdot. |
EU's Tech Sovereignty Package Includes 29 Pages on Open Source, Says Open Source Initiative | | Friday the Open Source Initiative welcomed the EU's new tech sovereignty package, noting that "over a third of the 29-page document is devoted to Open Source."
The nonprofit OSI — maintainers of the Open Source definition — submitted their official feedback in February, and notes that "many" of their key requests were addressed, "as well as some exciting new announcements!"
One of the biggest barriers to Open Source adoption has been public procurement. Too often, tenders have been designed around proprietary solutions, ignoring the benefits of Open Source and locking public institutions into closed ecosystems. The OSI called for procurement rules that prioritize interoperability, reusability, and vendor independence. The package takes a major step forward in this area. The EU pledges to make the public sector an anchor consumer for Open Source solutions. The Commission plans to reform procurement rules to remove barriers for Open Source, provide better guidance to EU countries on procurement criteria to avoid excluding Open Source, and uphold the "public money, public code" principle when procuring software development. Both proposals align with the OSI's feedback. The next critical step is the EU's public procurement law reform. The OSI will continue advocating to ensure these pledges translate into action.
Beyond procurement, the OSI highlighted challenges faced by Open Source communities in Europe, particularly difficulties accessing investment and expertise to commercialize and scale projects. The Commission has responded by committing to ensure Open Source companies are considered for funding under the European Competitiveness Fund (ECF). It also plans to create "Open Source business accelerators" that will offer mentorship, training, legal and licensing consulting, and business development support, including marketing. Additionally, the Commission will work to raise industry awareness of Open Source solutions by leveraging the EU's existing business support networks. These measures directly address the OSI's concerns and could significantly boost the Open Source ecosystem in Europe...
[I]n our feedback, we called for the continuation of the Next Generation Internet (NGI) initiative that has funded many Open Source projects, and for the creation of a European Sovereign Tech Fund to fund ongoing maintenance and features development to meet the EU's needs. We also highlighted the need to mainstream Open Source in other funding opportunities (like the €100bn+ Horizon Europe programme). The Commission's strategy addresses these requests. The NGI will be scaled up under the new name "Open Internet Stack." A new Open Source Maintenance Instrument will fund the "maintenance and security upkeep of essential components." The Commission will also create a list of critical and security-relevant Open Source dependencies to inform funding decisions and promote Open Source solutions as the default approach in Horizon Europe funding.
Friday's announcement from the Open Source Initiative notes that the EU is already leading by example in Open Source adoption. It applauds the EU for "deploying a Matrix-based communications system and the openDesk collaboration environment internally, trialing an alternative operating system to replace Windows, which is currently widely used in EU institutions, and expanding its presence on the Fediverse, with Commissioners and key departments already joining the EU's Mastodon server.' Read more of this story at Slashdot. |
Hospital Ordered to Pay $13M Over 2022 Death of Star Trek's Nichelle Nichols | | The Root reports:
A New Mexico jury has found the Gila Regional Medical Center negligent in the death of Nichelle Nichols, who famously played Lieutenant Nyota Uhura on the hit television series "Star Trek."
According to KRQE News 13, Nichols' family filed a lawsuit against the hospital last year following her 2022 admission for shortness of breath. Nichols' family claimed that she should have received a full cardiac examination, but the medical personnel sent her to the observation unit, and she was discharged the next day. After being transported to her assisted living home, the 89-year-old passed away just seven hours later.
In response to Nichol's tragic passing, the lawsuit alleged that Gila Medical Center "hired, credentialed, and inappropriately supervised unqualified medical providers" who treated the actress. The lawsuit also alleged that the hospital failed to secure a bed for Nichols or transfer her to a facility that had one. Furthermore, the attorney argued that the staff should have known that the assisted living center was not equipped to handle a patient with her medical needs.
On Thursday (June 4), a jury found the hospital negligent and awarded Nichols' estate $13 million.
KRQE got this quote from the estate's attorney about the death of the 89-year-old acctress. "At the end of the day, Nichelle Nichols had a heart attack that was missed. Thatâ(TM)s why she died." The jury deliberated for "just two hours." Read more of this story at Slashdot. |
Ladybird Browser Stops Accepting Public Pull Requests | | The Ladybird browser isn't opposed to AI coding tools, but it's just brought a new change to their code-contributing policies.
February 23: "Ladybird adopts Rust, with help from AI."
Our first target was LibJS , Ladybirdâ(TM)s JavaScript engine... I used Claude Code and Codex for the translation. This was human-directed, not autonomous code generation. I decided what to port, in what order, and what the Rust code should look like. It was hundreds of small prompts, steering the agents where things needed to go... The requirement from the start was byte-for-byte identical output from both pipelines. The result was about 25,000 lines of Rust, and the entire port took about two weeks. The same work would have taken me multiple months to do by hand.
June 5 (Friday):
We will no longer accept public pull requests... A pull request no longer tells us as much as it used to about the person submitting it. A substantial patch used to imply substantial effort, and that effort was a reasonable proxy for good faith. That assumption no longer holds....
We have already seen patient, well-resourced campaigns in open source to earn maintainer trust and abuse it. What has changed is how much faster and cheaper it has become to produce work that looks like a serious contribution... Whether code was typed by hand is beside the point. What matters is who is responsible for it once it enters the browser. Ladybird is becoming a browser for real users. The people introducing changes to it must be the people who decide those changes belong in the project, and who will answer for the consequences.
As part of this change, we will close all currently open public pull requests. We are grateful for the work people put into them, but keeping the existing queue open would keep that contribution path open in practice. There is no perfect time to make this change, so we are making it now. Going forward, pull requests will only be available to project maintainers. There will not be a separate process for submitting patches by other means. We do not want to create a shadow contribution system through issues, comments, email, or forks...
Outside involvement still matters: clear bug reports, reductions, website testing, standards discussion, design discussion, security reports, and technical feedback all help move the project forward. This is the right change for Ladybird now. We are preparing to ship a browser to real users, and our development process has to match that responsibility. Read more of this story at Slashdot. |
New Power Banks Released By BMX With Safer Semi-Solid-State Batteries | | From Android Authority:
Singapore-based BMX has announced that its SolidSafe magnetic power bank lineup, first showcased at CES 2026, is now available for purchase through its website and Amazon US, with prices starting at $59. What sets these power banks apart is their use of semi-solid-state batteries. Traditional lithium-ion and lithium-polymer batteries rely on liquid electrolytes to move energy between electrodes. Semi-solid-state batteries significantly reduce the amount of flammable liquid inside the cell, improving thermal stability and lowering the risk of overheating, swelling, or fire...
BMX says the power banks are designed to remain stable under extreme conditions and show greater resistance to physical damage and thermal stress than conventional battery packs. The company has also launched the SolidSafe Air, a 5,000mAh magnetic power bank that it claims is the world's thinnest semi-solid-state Qi2 power bank... BMX is positioning the device as a travel-friendly alternative for users who want added safety and the convenience of a magnetic battery pack without the bulk.
Thanks to long-time Slashdot reader destinyland for sharing the article. Read more of this story at Slashdot. |
Teen Social Media Bans Risk Strengthening Big Tech's Dominance, Warns Bluesky Exec | | Bluesky's chief operating officer believes teen social media bans "risk entrenching Big Tech's dominance," reports CNBC:
Rose Wang, Bluesky's chief operating officer, told CNBC on the sidelines of SXSW in London on Wednesday that the smaller open-source platform isn't opposed to regulation but that smaller players in the industry should be protected. "I support the protection and the safety of youth... The question that we have then is at what cost? Because essentially what I'm scared of is in the long term, we're headed to a world where there's about three to five platforms, and extreme heavy regulation of those platforms...
"Basically the whole compliance teams of these platforms are 10 times the size of our entire team," Wang said. "So, basically, we're living in a world where it's almost impossible for smaller entrants to come in and build healthier spaces."
The article notes Bluesky had grown to 43 million users as of March, "which is still only around 10% of X's estimated 450 million users. Bluesky has struggled to maintain popularity, and by the end of October last year, it had reportedly seen a 40% drop in daily mobile active users over the past 12 months." Read more of this story at Slashdot. |
Early Research Suggests a Path to Predict and Prevent Lung Cancer | | Scientists "have made a discovery that may help prevent some people from developing lung cancer," reports the New York Times, noting that lung cancer "kills more people worldwide than any other cancer."
A team of more than 80 researchers working across four continents have identified a set of proteins in the blood that accurately predict lung cancers more than five years before diagnosis. The scientists also found early evidence that an existing anti-inflammatory drug could significantly reduce lung cancer risk in people with elevated concentrations of these proteins, which they linked to inflammation. More research is needed before a test based on these proteins could be ready for use in patients. And scientists would still need to run a randomized trial to determine whether the drug prevents lung cancers. Still, outside experts said the findings, which were published on Thursday in the journal Cell, offer a promising starting point toward a long-held public health goal...
Led by Dr. Swanton, Dr. Tej Pandya, a Ph.D. student, and other researchers took a set of 48,000 blood samples from the UK Biobank and used machine learning to identify 14 proteins associated with the development of lung cancer. When the researchers looked at the presence of those proteins and also took into account a patient's age, smoking status and history of lung disease, they were able to predict who would develop lung cancer more accurately than the best risk assessment models currently in use...
Using mouse and cell models, the scientists showed that these proteins increased when a specific inflammatory pathway was activated. Smoking and air pollution can activate that pathway. This adds to the evidence that it isn't just genetic mutations caused by smoking, pollution or other factors that are driving lung cancers. Rather, Dr. Swanton said, the findings suggest that "smoke causes mutations and inflammation, which together cause cancer." They also found that the signature was increased in people who later developed chronic obstructive pulmonary disease and pulmonary fibrosis, pointing to a common inflammatory environment upstream of all three diseases.
Read more of this story at Slashdot. |
|
|
